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Integrative Therapeutics®



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Product Details


Berberine offers metabolic support for glucose and lipid metabolism.* It also supports healthy blood sugar and insulin levels already within a normal range.*

Clinical studies demonstrate that berberine supports healthy lipid metabolism and cholesterol homeostasis.*1-6 Berberine can activate an important metabolic enzyme known as adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.* Mechanistic research in vitro and in vivo suggests that berberine can decrease cholesterol and triglyceride synthesis by activating AMPK.7-9

In addition to supporting lipid metabolism, berberine supports healthy glucose metabolism and blood sugar management already within a normal range.*2-5 Mechanistic research in vitro suggests that berberine can support healthy glucose regulation through promoting glucose uptake in cells via GLUT4 translocation.7


  1. Kong W et al. Nat Med. 2004;10(12):1344-51.
  2. Yin J et al. Metabolism. 2008;57(5):712-7.
  3. Zhang Y et al. J Clin Endocrinol Metab. 2008;93(7):2559-2565.
  4. Yang J et al. Evid Based Complement Alternat Med. 2012;2012:363845.
  5. Perez-Rubio K et al. Metab Syndr Relat Disord. 2013;11(5):366-9.
  6. Cao C et al. Exp Ther Med. 2019;17(4):3009-3014.
  7. Lee YS et al. Diabetes. 2006;55:2256-64.
  8. Brusq JM et al. J Lipid Res. 2006;47(6):1281-8.
  9. Jiang D et al. Lipids Health Dis. 2016;15:214.



Serving Size:   Amount/Serving %DV
Berberine HCl 500mg

** Daily Value (DV) not established
†Percent daily value is based on a 2000 calorie diet

Other Ingredients
plant-derived capsule (hypromellose), cellulose, calcium laurate, silica

Berberine Does Not Contain
Wheat, Gluten, Corn, Soy, Dairy, Colors, Artificial Flavors, Preservatives


Berberine Directions and/or Dosage

Adults take 1 capsule two to three times daily, or as recommended by a healthcare professional.


Do not use if you are pregnant or nursing. If you have diabetes, or are taking any prescription drugs, consult a healthcare professional before use. Keep out of reach of children. Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

 Highlights: Wheat-Free, Gluten-Free, No Corn, Soy-Free, Dairy-Free, No Artificial Colors, No Artificial Flavors, No Preservatives, Vegan


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Labels and packaging may change without warning from manufacturer.
Please consult the actual product label for the most accurate product information and directions for proper use.
The Natural Alternative Nutrition Center does not provide medical advice or consultation. Consult your physician before ordering and/or using any product available on our website.
We do not guarantee carrier calculated deadlines for shipping.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.