The Natural Alternative

Highlights Active Iron includes high-concentration, gentle iron to support energy production and a variety of other protocols. Provides Safe, Highly-Absorbed Iron for a Variety of Protocols High-Concentration Iron for Energy Support Supports Oxygen Transport and Energy Production Iron is one of the most abundant minerals on earth. It is essential to the majority of life forms, especially human physiology. Iron supports prenatal and cognitive health, as well as energy balance. Iron is an integral component of the proteins involved in oxygen transport and storage: hemoglobin, myoglobin and ferritin. Iron, as part of the protein hemoglobin, carries oxygen from the lungs to various parts of the body. Hemoglobin accounts for nearly two-thirds of the iron found in the body, and carries essential oxygen to tissues and organs. Approximately one-sixth of the body’s iron is stored as ferritin for use when dietary intake is not sufficient. Iron must be maintained at balanced levels within the body—too much can cause toxicity and too little may lead to impairment of optimal health outcomes. Iron has to be carefully absorbed by the body. Interference can easily occur, making adequate consumption through diet and supplementation imperative to achieving a healthy balance. Active Iron provides 29 mg of elemental iron per serving, ideally formulated using the amino acid chelate form of iron (ferrous bisglycinate) for enhanced absorption, optimal utilization and gastrointestinal (GI) comfort. Some individuals, who take other forms of iron supplements, may experience GI side effects, including gas, bloating, constipation or a combination of these symptoms. Supplementing the right form of iron can be key to maintaining healthy levels within the body and compliance to a supplement regimen. Suggested Use: 1 capsule per day or as recommended by your health care professional. Bioavailability The importance of bioavailability is obvious. If consuming an iron supplement has little effect on improving the body’s iron balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rock-salt minerals. Active Iron is formulated with the superior amino acid chelate form, ferrous bisglycinate, which does not ionize in the gut. Like heme iron (the most bioavailable form of iron found in some protein food sources), Ferrochel® Ferrous Bisglycinate is not impacted by dietary factors and is absorbed at a 59% higher rate than lesser forms, such as ferrous sulfate. Comparison studies have shown significantly superior absorption of the iron chelate form compared to other rock-salt forms (most commonly ferrous sulfate): Iron from Ferrochel® Ferrous Biglycinate shows absorption rates 59% higher than ferrous sulfate Ferrochel® iron is absorbed at a rate 3.8 times higher than ferrous sulfate Ferrochel® iron shows a reduced number of adverse complaints compared to ferrous sulfate No complaints of side effects were reported by subjects at 30 mg per serving Energy Balance Iron supplements are often a standard recommendation for the treatment of fatigue, particularly among women. A 2012 randomized study confirmed the efficacy of iron in supporting energy balance. French researchers studied nearly 200 menstruating women ages 18 to 53 who complained of fatigue but were otherwise healthy. All subjects had lower-than-normal ferritin levels (less than 50 mcg per liter). During the study, half of the subjects took 80 mg of iron daily, while the other half took a placebo. Fatigue was measured using a validated questionnaire at the beginning and end of the study. At the close of 12 weeks, patients receiving the iron pills reported favorable outcomes related to fatigue and energy balance compared to the placebo group. The researchers also found that iron supplements increased the production of red blood cells. Prenatal Support Several major health organizations recommend iron supplementation during pregnancy to ensure pregnant women meet their iron requirements for healthy pregnancy outcomes. For all pregnant women, the Centers for Disease Control and Prevention recommends routine low-dose iron supplementation beginning with the first prenatal visit. Larger doses of iron may be recommended following thorough testing to determine low hemoglobin or hematocrit. Cognitive Health In a 2013 study published in the Canadian Medical Association Journal, daily iron supplementation was shown to support outcomes associated with cognitive health, including attention and concentration. Additionally, the same study found that healthy outcomes were supported related to incidences of general iron deficiency.

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 Active Mag includes three forms of highly absorbed magnesium for a variety of protocols. Provides Three Forms of Highly Absorbed Magnesium for a Variety of Protocols High-Concentration Magnesium for Cardiovascular Support Helps Maintain Healthy Blood Pressure and Glucose Levels Promotes Energy Production and Muscle Relaxation Magnesium is an abundant mineral in the body and is found naturally in many foods, like green leafy vegetables. It is also found in over-the-counter medications, such as laxatives. The average American intake of magnesium, according to the National Health and Nutrition Examination Survey (NHANES Study) is critically low: Many Americans fail to consume the estimated average requirement (EAR) established by the Institute of Medicine. In addition, more than 57% of the population does not meet the United States Department of Agriculture requirements for magnesium in the diet. Intracellular magnesium levels are decreased by excessive intake of alcohol, salt, coffee, phosphoric acid found in sodas, diets high in calcium and high stress levels. Because of widespread nature of magnesium deficiencies, adequate daily intake of magnesium is critical for proper hydration, stress response, muscle relaxation, promoting healthy blood pressure levels, optimal bone mineral density, and blood sugar regulation. Active Mag provides three unique forms of highly-absorbed magnesium to ensure maximum absorption of this important macromineral. Most magnesium supplements use only a single source of magnesium, which can easily overwhelm a single pathway of absorption and limit uptake. Reacted Magnesium takes advantage of three unique pathways of absorption by providing magnesium as di-magnesium malate, magnesium citrate and magnesium glycinate for enhanced absorption, improved utilization and gastrointestinal (GI) comfort. Some individuals, who take other forms of magnesium supplements, often experience GI side effects, including gas, bloating, diarrhea, constipation or a combination of these symptoms. The forms of magnesium used in Reacted Magnesium preserve GI comfort while maximizing absorption and restoring magnesium levels in the body. Suggested Use: 2 or more capsules per day or as recommended by your health care professional. Bioavailability - The Mineral Chelate Difference The importance of bioavailability is obvious. If consuming a magnesium supplement has little effect on improving the body’s magnesium balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rock-salt minerals like calcium carbonate and magnesium oxide. These mineral forms slow and limit absorption, relying on adequate stomach acid to release magnesium ions which then enter the body via passive diffusion. And, because they tend to remain in the intestines longer, these forms of mineral supplements can cause intestinal distress such as constipation (calcium carbonate) or diarrhea (magnesium oxide). In addition, other comparison studies have shown significantly superior absorption of magnesium chelates compared to other mineral forms: At a dose of 400 mg, magnesium chelate significantly reduced or eliminated menstrual abdominal discomfort. Multiple double blind studies found urinary excretion of magnesium chloride higher than magnesium glycinate, proving superior absorption. Magnesium glycinate is shown to have a reduced laxative effect when compared to other forms of magnesium. Mineral chelates are gentle, gut “friendly” minerals that do not cause diarrhea that often accompanies magnesium oxide and other rock-salt forms. Albion®’s mineral chelates have extensive clinical research proving their superior bioavailability, biologic activity, stability, and improved tolerance.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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The special blend of vitamins and adaptogenic herbs in Adren-Adapt supports normal adrenal function during occasional stress and fatigue. Improves Stress Resilience Supports Healthy Energy Levels Strengthens the Body’s Stress Response Improves Mental and Physical Performance Helps Maintain a Balanced Cortisol-to-DHEA ratio Stress is defined as any disturbance–extreme cold or heat, psychological stress, sleep deprivation, work overload, physical trauma, as well as toxic exposure, that can trigger the stress response. The body’s stress response system is comprised of the hypothalamic-pituitary-adrenal (HPA) axis. Prolonged stress triggers the HPA axis and consists of three stages: stage 1: alarm; stage 2: resistance; and stage 3: exhaustion.  The initial, short-lived phase (the alarm phase) is the body’s normal fight-or-flight response to danger which is characterized by elevated cortisol levels. The next phase, the resistance phase, allows the body to continue buffering extended stress exposure, long after the initial fight-or-flight response has dissipated. Hormones released by the adrenals, such as cortisol and DHEA, help support the "resistance" reaction. However, extended periods of stress not only burden the system, creating an imbalance in cortisol and DHEA production, but can result in mental and physical fatigue, nervous tension, irritability and poor memory of which are characteristic of stage 3. Adrene-Adapt offers a unique blend of botanicals, adrenal concentrate and micronutrients that support the adrenals glands, as well as the body’s ability to respond to and counter-act the negative effects of stress. Adren-Adapt contains a blend of key micronutrients, adaptogenic botanicals and adrenal concentrate specifically formulated to strengthen the body’s stress response and support healthy energy levels. Adren-Adapt provides targeted amounts of vitamin A and C, pantothenic acid, and other B vitamins that are critical to adrenal gland function. This powerful formulation helps support the body’s resistance to fatigue and aids in maintaining balanced cortisol and DHEA levels. Suggested Use: 2 capsules one to two times per day or as recommended by your health care professional.   Rhodiola rosea Root ExtractRhodiola rosea has been categorized as an adaptogenic botanical due to its ability to increase resistance to a variety of stressors. Rhodiola has been studied extensively andis widely used in Eastern Europe and Asia to help support the nervous system, mood regulation, mental clarity, work performance and the sleep cycle. Within the central nervous system, Rhodiola has demonstrated an ability to preserve levels of neurotransmitters such as serotonin, dopamine and norepinephrine. In a randomized, double-blind, placebo-controlled study examining the effects of Rhodiola on fatigue and stress, 161 patients aged 19 to 21 years received Rhodiola twice daily resulting in a significant reduction in fatigue. An additional study using Rhodiola extract in students showed significant improvements in mental performance, greater mood stability, and improved sleep patterns.Eleuthero Root ExtractEleutherococcus senticosus has been identified as a strong adaptogenic botanical and is widely used in China to support general health, memory and endurance. In addition to its ability to improve stress resilience and fight fatigue, Eleuthero has exhibited immune supporting effects. In a double–blind study, 45 healthy volunteers received Eleuthero or placebo for 30 days. A cognitive challenge test was given to assess stress response, along with heart rate. Unlike placebo, subjects receiving Eleuthero demonstrated a 40% reduction in heart rate in response to the stressor. Eleuthero has also been shown to improve performance in runners. In a study on performance athletes, Eleuthero extract (2 or 4 mL) given 30 minutes prior to a race significantly reduced race time (48.7 minutes) compared to the control group (52.6 minutes).Schizandra Berry ExtractSchizandra is an adaptogenic botanical that has been used for centuries in China and Russia to help support mental clarity, stress response and emotional wellness. In a double-blind, placebo-controlled study, athletes who were given an adaptogenic blend including Schizandra chinensis extract or placebo, had increased concentrations of nitric oxide, a molecule which causes the blood vessels to expand resulting in increased circulation, increased blood flow and nutrients throughout the body and healthy blood pressure. The researchers concluded that Schizandra enhances physical performance in athletes. Schizandra berry has been shown to support learning and memory and may have a protective effect on brain health.Licorice Root ExtractThe primary components in licorice root that support adrenal health include glycyrrhetic acid and glycyrrhizin. Licorice has also been shown to block 11-ß-hydroxysteroid dehydrogenase, the enzyme responsible for the conversion of cortisol to the inactive cortisone. When taken in small doses, licorice root extract can be used to maintain cortisol levels, an important factor for individuals that need to support adrenal hormone production and maintain healthy inflammatory pathways.Adrenal ConcentrateThe use of glandular concentrates to supply key nutrients to support the body has been used in medicine for thousands of years. The concept behind glandular therapy is based on the idea that similar organ extracts from animals will support the same organ within humans by stimulating its activity.Adrenal bovine concentrate allows for rejuvenation of the adrenal stress system in a balanced and efficient manner.Micronutrient BlendAdrenal gland function, as well as the synthesis of cortisol, is dependent on an adequate supply of various vitamins. Vitamin C levels are among the highest in the adrenal glands compared with other organs. Vitamin C plays a major role in neurotransmitter production and supports general health of the adrenals. Under stressful conditions, vitamin C and B complex vitamins are readily used and excreted from the body. Within the B vitamin family, pantothenic acid breaks down into coenzyme A, which is essential for the production of energy from ingested carbohydrates, fats and proteins. In a study evaluating the effects of pantothenic acid and glutathione production, pantothenic acid was found to increase CoA levels in the body, leading to increased energy production. Niacin also plays a vital role in many metabolic functions in the body, including supplying energy to cells and assisting in the production of adrenal hormones.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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Highlights Aloe 450 includes ingredients for regularity that work fast, without the artificial additives and associated cramping common in some products.  Supports Gastrointestinal Function Supports Bowel Regularity Cape aloe has been used for thousands of years to promote the health of epithelial tissue, including the bowel lining. Cape aloe contains a class of phytonutrient compounds called anthraquinone glycosides. When ingested, these compounds are activated through bacterial metabolism in the gut, promote water retention in the stool, and stimulate peristalsis in the large intestine. By causing active chloride secretion, cape aloe increases the water and electrolyte content in the stool and eases elimination without artificial additives and cramping associated with other therapies. Aloe 450 is intended for the relief of occasional constipation. Cape aloe, the solid residue obtained by evaporating liquid aloe ferox, has been shown in the research to affect regularity due to its influence on colon peristalsis, which it triggers to contract, resulting in accelerated intestinal passage.  Suggested Use: 1 capsule at bedtime (allow 24 hours before redosing) or as recommended by your health care professional. Cape Aloe Despite the lack of published studies, aloe preparations have been in the United States Pharmacopoeia for more than 100 years. Anecdotal evidence suggests cape aloe supports normal inflammatory response in the gastrointestinal tract. Studies demonstrate that cape aloe increases stool bulk and bowel transit time and improves microflora balance. Cape aloe also supports the colon to help maintain a healthy gastrointestinal tract

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Highlights Helps Maintain Healthy Cholesterol Levels Already Within the Normal Range Multidimensional Support for Cardiovascular Health Preserves Arterial Health and Elasticity Supports Healthy CoQ-10 Levels Optimizing cardiovascular health is a leading concern for many adults, and maintaining balanced cholesterol levels are an important part of that process. Though cholesterol can be consumed through food, circulating cholesterol levels are primarily produced and controlled by the liver using the rate control enzyme, HMG-CoA reductase (HMGCR). Because of its pronounced role in cholesterol synthesis, inhibiting HMGCR has become a primary target of many traditional therapies. Numerous clinical trials have shown the specific BPF found in Bergamot BPF works at the level of the liver to help maintain and support healthy cholesterol levels and preserve coronary arteries by maintaining normal inflammatory balance. Suggested Use: 2 capsules per day or as recommended by your health care professional. What are Bergamot Polyphenolic Fractions? Bergamot (Citrus bergamia) is a citrus plant that grows almost exclusively in the narrow coastal Calabria region in southern Italy. The local population quickly discovered bergamot juice could be used to help support healthy cholesterol levels and optimize cardiovascular wellness. Bergamot’s health benefits derive from its unique profile of phenolic compounds such as, neoeriocitrin, neohesperidin, naringin, rutin, neodesmin, rhoifolin and poncirin. Naringin has been shown to be beneficial in maintaining normal inflammatory balance, while neoeriocitrin and rutin have been found to exhibit a strong capacity to quench free radicals and maintain healthy LDL cholesterol levels. Also, bergamot is rich in brutieridine and melitidine, which have a unique ability to dampen HMG-CoA reductase.

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In addition to supporting bone health, vitamin D plays an important role maintaining cardiovascular health and immune function, and promoting an overall sense of well-being. Product Overview Clinical Applications Maintains Bone and Dental Health Increases Calcium Absorption and Balance Boosts Immune Activity Supports Cardiometabolic Health, Blood Sugar Balance Already Within Normal Levels, and Weight Loss Helps Increase Musculoskeletal Strength and Comfort D3 50,000 is a steroid hormone that is part of a group of fat-soluble pro-hormones best known for the role they play in supporting bone health and aiding in the absorption of calcium and phosphate from the gastrointestinal tract. A growing body of research highlights vitamin D's important role in supporting other body systems, including cardiovascular and blood sugar balance, musculoskeletal strength, and neurological and immune function, enabled by vitamin D's ability to target over 200 different genes throughout the body.D3 50,000 IU is ideal for those who have difficulty achieving and maintaining peak vitamin D levels. For those who require an immediate boost in their vitamin D status, the vitamin D3 50,000 IU formulation is a convenient, effective way to get the substantial support they need. Suggested Use:1 capsule per week. This product is a high dose vitamin D capsule that is not typically intended for long-term daily use. Please consult your health care professional if you are unsure of the appropriate dose. Benefits Vitamin D DepletionWhile it has long been assumed that the majority of the population achieves adequate levels of vitamin D through exposure to the sun, the biosynthesis of the nutrient is affected by time of day, seasons, location, smog/pollution, clothing and sunscreen. Depleted levels of vitamin D may interfere with the normal development of teeth and bones, normal cell growth, and contribute to poor regulation of immune and nervous systems. Bone and Dental HealthNumerous studies have highlighted the importance of vitamin D to maintaining healthy bone density.Cardiometabolic Health and Blood Sugar BalanceIn light of the role that vitamin D plays in a variety of tissues and body systems, it comes as no surprise that much research from recent years has underscored its contribution to cardiometabolic wellness. Vitamin D has also been shown to support healthy blood sugar metabolism. Immune Health and ModulationOne of the more profound functions of vitamin D is its ability to modulate immunity. An important recent study suggested that improving vitamin D status significantly affects the expression of genetic pathways linked to immune activity. Vitamin D has been shown to boost the immune response by up-regulating specific genes.Musculoskeletal ComfortNumerous studies also point to the key role of vitamin D in supporting musculoskeletal strength and comfort.Safety and Efficacy of High Dose Vitamin DVitamin D research is continually evolving and now includes safety and efficacy studies on high doses of up to 50,000 IU. Vitamin D 50000 Supplement Facts Serving Size 1 Capsule Servings Per Container 15  Amount Per Serving % Daily Value Vitamin D (D3 as Cholecalciferol) 1,250 mcg (50,000 IU) 6,250%

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Highlights Vitamins K and D act in synergy in the process of supporting and maintaining bone, cardiovascular and immune health.  Supports Healthy Calcium Balance Promotes Optimal Bone Health Supports Cardiovascular Health and Arterial Elasticity Boosts Immune Function Emerging research highlights the importance of optimal intake of vitamin K and its critical role in maintaining bone and cardiovascular health. Composed of a group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is required for the proper utilization of calcium and helps to bind newly absorbed calcium to the bone matrix. Vitamin K helps maintain bone mineral density by decreasing the activity of osteoclasts, cells that break down bone. It also provides critical cardiovascular protection by activating matrix Gla protein (MGP), a potent inhibitor of circulatory calcification. Along with vitamin D, another key nutrient required for overall wellness, these two nutrients act in synergy to support and maintain bone and cardiovascular health. Current research has found high concentration supplementation, at 180 mcg/day, results in improved clinical results compared to lower-dose supplementation. Suggested Use: 1 capsule per day or as recommended by your health care professional. Vitamin K Depletion Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K, through its carboxylation of osteocalcin, a protein secreted by osteoblasts. Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in two main forms: K1 (phylloquinone), derived from foods such as green leafy vegetables and K2 (menaquinone), which is a group of related compounds differentiated by their side chains. Numerous studies have shown that vitamin K2 as MK-7 is the more bioavailable form of the nutrient 7 and more powerfully influences bone building than K1.  Bone Health Supplementation of K2 has repeatedly been shown to help maintain bone density and strength among women.  Cardiovascular Health and Blood Sugar Balance Vitamin K also plays a key role in supporting the cardiovascular system and healthy blood sugar balance. In a large population study, those who consumed high amounts of K2 had significantly improved cardiovascular markers compared to those given vitamin K1. Triage Theory The Triage Theory states that in the face of nutrient inadequacies, nature ensures the short-term survival of a cell is protected at the expense of long-term consequences. Vitamin K is an excellent example of this theory. Hypothetically, a short-term deficiency in vitamin K would lead to a reduction in blood clotting. This direct threat to survival does not happen because the body uses its metabolic reserve of vitamin K to ensure immediate needs are met. If prolonged, this dip into nutrient reserves leads to a long-term deficiency in vitamin K. Though not directly threatening immediate survival, long-term deficiencies are linked to bone fragility, arterial calcification and genomic instability.   

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Highlights DIM Complex  is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM) to support balanced estrogen metabolism. Supports Estrogen Balance Supports Proper Estrogen Metabolism for Women and Men Improves Estrogen Detoxification Pathways Provides Cellular Antioxidant Support for DNA Stability Hormones (especially estrogen) are critically important in human development and tissue repair. However, estrogen’s proliferative effects must be balanced and controlled for optimal health. Therefore, to ensure proper hormonal balance, estrogen synthesis and detoxification should be supported. Estrogen has several downstream metabolites, of which some are beneficial while others possess potentially harmful biological activity. By keeping hormones in balance and ensuring the body can process estrogen properly, cruciferous vegetable metabolites (i.e., I3C and DIM) work together to maintain cellular health. DIM Complex is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM) to support balanced estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites that work together to support estrogen balance, breast and prostate health. I3C & DIM Indole-3-carbinol (I3C) and diindolylmethane (DIM) are natural metabolites of compounds found in numerous vegetables from the Brassicaceae family. Both I3C and DIM, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C and DIM have been shown to induce some phase I and phase II biotransformation genes in preclinical models through pathways such as Nrf2, suggesting I3C and DIM may have a role in detoxification. Additionally, both I3C and DIM have been shown in vitro to decrease aromatase expression, the enzyme that converts androgens to estrogen. Suggested Use: 1 capsule per day or as recommended by your health care professional.  

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Hist Assist formula includes optimal support for nasal and sinus passageways for individuals who anticipate seasonal changes. Supports Immune Balance in Hypersensitive Individuals Supports Sinus and Respiratory Health Promotes Normal Viscosity of Mucus Supports Healthy Nasal Passages Hist Assist is a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. The formula includes quercetin, bromelain, stinging nettles leaf and N-acetyl cysteine. The powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation. Suggested Use: Loading Dose: 2 capsules three times per day for 7-10 days or as recommended by your health care professional. Maintenance: 2 or more capsules per day or as recommended by your health care professional. Quercetin Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants including oak trees, onions and tea. Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes. Stinging Nettles Leaf Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Stinging nettles leaf controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response. Bromelain Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin. Bromelain has been shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort. N-Acetyl Cysteine N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health.  Vitamin C Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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  Hist Assist Jr. promotes healthy nasal and sinus passages for children with elevated histamine and respiratory irritation. Supports Immune Balance in Hypersensitive Children Supports Sinus and Respiratory Health Promotes Normal Viscosity of Mucus Clears Nasal Passages Hist Assist Jr. is a great-tasting, chewable tablet that includes a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for children with seasonal challenges caused by common environmental allergens. Hist Assist Jr. includes quercetin, a powerful flavonoid to support healthy histamine levels. It supplies bromelain to enhance the absorption of quercetin and to support mucosal tissue health and stinging nettles leaf to balance hyper-immune response. N-acetyl cysteine clears the airways by promoting normal viscosity of mucus. This unique nutritional combination safely promotes healthy nasal and sinus passages for children with elevated histamine and respiratory irritation. Suggested Use: 1 tablet as needed or as recommended by your health care professional. Quercetin Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants, oak trees, onions and tea leaves. Quercetin has strong antioxidant activity and has also been shown to support immune health by mediating the release of inflammatory compounds, including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, which diminishes the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes. Stinging Nettles Leaf Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances several of inflammatory activities that affect respiratory health. In addition to controlling mast-cell degranulation, stinging nettles leaf controls prostaglandin formation and histamine action, thus contributing to a balanced inflammatory response. Bromelain Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in the breakdown of large protein complexes, including antigenic compounds. Bromelain has been shown to enhance the absorption of quercetin and to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort. N-Acetyl Cysteine N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body: glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health. Vitamin C Because vitamin C cannot be synthesized by the human body, it is an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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Methyl B includes a concentrated and bioavailable source of two key B vitamins: B12 and folate. This comprehensive blend helps support numerous systems in the body. Includes High-Concentration, Fast-Absorbing Bioactive Methylcobalamin and Methylfolate (100% as 5-MTHF) Boosts Energy Levels and Supports Red Blood Cell Production Promotes Cardiovascular Health and Homocysteine Balance Rejuvenates Nerve Cell Function and Boosts Cognitive Health Supports a Positive Mood and Healthy Sleep Cycle Regulation Vitamin B works along with folate in many body processes. These include increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function, up-regulating methylation, increasing DNA synthesis and repair, and supporting the formation of the protective myelin sheath, the insulating exterior that speeds up nerve cell transmission.Most B supplements contain cyanocobalamin. In order for B to be utilized in the body, the liver must first remove the cyanide molecule and attach a methyl group to form methylcobalamin, the biologically active, tissue-ready form. Research has shown that methylcobalamin is more efficiently used and retained in the body than the cyanocobalamin form.This formulation of Methyl B includes a concentrated and bioavailable source of two key B vitamins: B12 and folate.Suggested Use:1 tablet per day or as recommended by your health care professional.   Energy Support Vitamin B plays a large role as a cofactor in enzymes involved in the metabolism of proteins, fats and carbohydrates, and is required to produce succinyl CoA, an intermediary in the Kreb's cycle that generates cellular energy in the form of adenosine triphosphate (ATP). Due to its role in the production of ATP, vitamin B deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels.Peripheral Circulation and Nerve Cell HealthIn a double-blind study, oral administration of methylcobalamin (500 mcg three times daily for four months) showed a significant improvement in neuromuscular health. The subjects in the control group reported improvement in muscle aches, fatigue, sensitivity to pain, circulation, muscle cramps and reflexes.Cardiovascular Health and Homocysteine BalanceHomocysteine is a molecule which is synthesized in the body from the amino acid methionine. Maintaining healthy homocysteine balance is crucial for supporting arterial and cardiovascular health. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance. 5-MTHF acts as a methyl donor, providing a methyl group to vitamin B12. The methylated form of B (methylcobalamin) then transfers the methyl group to homocysteine, resulting in consistent recycling of homocysteine to methionine.Mental and Cognitive HealthB has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of s-adenosylmethionine (SAM-e), a nutrient that has powerful mood and sleep-cycle regulating properties. Due to B12’s ability to increase the production of neurotransmitters and nerve cell transmission, B12 has been shown to improve cognitive function. 5-MTHF plays a significant role in mood regulation as it is required as a methyl group donor for the production of neurotransmitters such as serotonin. Sleep Cycle RegulationMethylcobalamin and 5-MTHF are both required nutrients for the biosynthesis of melatonin, the hormone that helps induce sleep. Within the central nervous system, the neurotransmitter serotonin is converted into melatonin in a pathway that requires the donation of a methyl group.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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Methyl B12 includes a concentrated and bioavailable source of two key B vitamins: B12 and folate. This comprehensive blend helps support numerous systems in the body. Includes High-Concentration, Fast-Absorbing Bioactive Methylcobalamin and Methylfolate (100% as 5-MTHF) Boosts Energy Levels and Supports Red Blood Cell Production Promotes Cardiovascular Health and Homocysteine Balance Rejuvenates Nerve Cell Function and Boosts Cognitive Health Supports a Positive Mood and Healthy Sleep Cycle Regulation Vitamin B12 works along with folate in many body processes. These include increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function, up-regulating methylation, increasing DNA synthesis and repair, and supporting the formation of the protective myelin sheath, the insulating exterior that speeds up nerve cell transmission.Most B12 supplements contain cyanocobalamin. In order for B12 to be utilized in the body, the liver must first remove the cyanide molecule and attach a methyl group to form methylcobalamin, the biologically active, tissue-ready form. Research has shown that methylcobalamin is more efficiently used and retained in the body than the cyanocobalamin form.This formulation of Methyl B12 includes a concentrated and bioavailable source of two key B vitamins: B12 and folate. Suggested Use:1 tablet per day or as recommended by your health care professional.   Energy Support Vitamin B12 plays a large role as a cofactor in enzymes involved in the metabolism of proteins, fats and carbohydrates, and is required to produce succinyl CoA, an intermediary in the Kreb's cycle that generates cellular energy in the form of adenosine triphosphate (ATP). Due to its role in the production of ATP, vitamin B12 deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels.Peripheral Circulation and Nerve Cell HealthIn a double-blind study, oral administration of methylcobalamin (500 mcg three times daily for four months) showed a significant improvement in neuromuscular health. The subjects in the control group reported improvement in muscle aches, fatigue, sensitivity to pain, circulation, muscle cramps and reflexes.Cardiovascular Health and Homocysteine BalanceHomocysteine is a molecule which is synthesized in the body from the amino acid methionine. Maintaining healthy homocysteine balance is crucial for supporting arterial and cardiovascular health. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance. 5-MTHF acts as a methyl donor, providing a methyl group to vitamin B12. The methylated form of B12 (methylcobalamin) then transfers the methyl group to homocysteine, resulting in consistent recycling of homocysteine to methionine.Mental and Cognitive HealthB12 has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of s-adenosylmethionine (SAM-e), a nutrient that has powerful mood and sleep-cycle regulating properties. Due to B12’s ability to increase the production of neurotransmitters and nerve cell transmission, B12 has been shown to improve cognitive function. 5-MTHF plays a significant role in mood regulation as it is required as a methyl group donor for the production of neurotransmitters such as serotonin. Sleep Cycle RegulationMethylcobalamin and 5-MTHF are both required nutrients for the biosynthesis of melatonin, the hormone that helps induce sleep. Within the central nervous system, the neurotransmitter serotonin is converted into melatonin in a pathway that requires the donation of a methyl group.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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Highlights Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and maintain normal ranged blood pressure levels. Supports Healthy Blood Flow and Circulation Supports Healthy Fibrin Levels Helps Maintain Healthy Blood Pressure Supports Overall Cardiovascular Health Maintaining healthy blood circulation and balanced coagulation is a key part of supporting cardiovascular health. Fibrinolytic enzymes, such as plasmin, produced in the endothelial cells are responsible for ensuring proper blood flow. However, production of these enzymes decreases with age, which can result in increased fibrin levels. Nattokinase also inhibits a key enzyme resulting in arterial dilation to help maintain healthy blood pressure levels, and can generate tissue plasminogen activators helping to promote blood flow. Because it is a highly purified extract derived from soybeans, supplementing nattokinase differs from consuming soybeans in that nattokinase escapes the typical breakdown by digestive enzymes, and is absorbed and taken into the body directly from the small intestine to exert its effects in the plasma. Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and blood pressure levels. Derived from a highly purified extract of the traditional Japanese food natto, nattokinase is a natural, highly active enzyme that helps promote normal levels of fibrin. Fibrin is a filamentous protein formed in blood, which can accumulate along blood vessel walls and affect blood flow. Research has shown nattokinase closely resembles plasmin, the only endogenous enzyme that directly dissolves fibrin. It is thought to increase the body’s production of plasmin. Nattokinase has been shown to support activation of many of the body’s 3,000 endogenous enzymes. In addition, while many of the agents involved in promoting healthy blood flow and coagulation either have limitations, and or serious side effects, this formulation of Nattokinase has a potent support activity that lasts for an 8-12 hour period and is safe for long-term use. Each capsule of Nattokinase contains 100 mg of nattokinase. Suggested Use: 1 soft gel capsule two times per day or as recommended by your health care professional.

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  Strontium is a mineral that is similar physical and chemical properties to calcium. Research has shown strontium provides all-natural bone support. Provides Musculoskeletal Support Provides All-Natural Bone Support Increases Skeletal Strength and Helps Maintain Bone Density Bone is the rigid structure that makes up our skeleton, but is actually an active, living organ that is constantly being built up and broken down by osteoblasts and osteoclasts. The proper balance of this cycle and turnover of bone provides the foundation for strong bones over a lifetime.Strontium is a mineral that is similar physical and chemical properties to calcium. Research has shown strontium provides all-natural bone support through its ability to naturally increase the formation of osteoblasts (cells that build up bone) and slow down the formation of osteoclasts (cells that break down bone tissue), helping to maintain healthy bone density.Suggested Use:1 capsule two times per day or as recommended by your health care professional. For maximum absorption, do not consume with calcium supplements. Bone and Skeletal HealthA growing body of research highlights the benefits of strontium in skeletal health. A head-to-head study comparing SrC to strontium ranelate (SrR) in rats found both forms deliver equivalent amounts of elemental strontium. In the study, equivalent doses of both forms of strontium or placebo were given and assimilation into bone was compared for 19 weeks and followed for another eight weeks. The study confirmed the equivalent delivery of SrC into bone compared to SrR and potential of SrC to support bone structure.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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Highlights Formulated Specifically for Patients with Occasional Sleeplessness Promotes Calmness and Relaxation Supports Normal, Uninterrupted Sleep Provides Comprehensive Neurotransmitter Support Sleep is the body’s way of metabolically and psychologically resetting itself. The body’s circadian rhythm is regulated by an internal biological clock with an approximate 24-hour cycle. In order to maintain restorative sleep, it is crucial that the brain has optimal levels of serotonin and gamma-aminobutyric acid (GABA), the relaxing and sleep-regulating neurotransmitters, as well as the sleep-regulating hormone melatonin. The synergistic ingredients in Tranquility PM, boosts levels of the neurotransmitters and hormones that promote relaxation prior to bedtime and increase the deep, restorative stages of sleep. Suggested Use: 4 capsules taken one to two hours before bedtime or as recommended by your health care professional. 5-HTP The sleep-regulating hormone melatonin requires the essential amino acid L-tryptophan for conversion. A deficiency of L-tryptophan in the diet can lead to low serotonin and melatonin levels, which can contribute to sleep challenges. L-tryptophan is converted into the amino acid intermediate 5-hydroxytryptophan (5-HTP), which is then converted directly into serotonin, followed by melatonin conversion. Phosphatidylserine Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain. Phosphatidylserine has been shown to play a role in regulating cortisol excretion. Elevated levels of cortisol throughout the night can contribute to frequent waking. When taken in the evening, PS can help reduce cortisol excretion from the body’s stress response system, the hypothalamic-pituitary-adrenal (HPA) axis, in order to promote a healthy sleep cycle. Taurine Taurine is an amino acid that is found abundantly in the brain and has neuroprotective properties. Taurine promotes inhibitory neurotransmission by activating GABA receptors. Taurine also supports inhibitory neurotransmission by activating glycine receptors in the brain. Mineral Blend Calcium and magnesium are two minerals that play a major role in supporting a healthy sleep cycle. Magnesium calms the nervous system and has been shown to play a role in the regulation of the HPA axis. Magnesium promotes relaxation by decreasing the activity of glutamate, the primary excitatory (stimulating) neurotransmitter in the brain. Calcium ions are a critical requirement in the synthesis of melatonin. The combination of 5-HTP and calcium in Tranquility PM provides a significant and natural boost to melatonin levels, aiding in the conversion and activation of this crucial sleep hormone.

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  Ultra Digestzyme is a comprehensive blend of enzymes used to support healthy digestion and maximize nutrient absorption. Supports Healthy Digestion and Maximizes Nutrient Absorption Supports Gastric Acid Balance and Digestive Function Provides Protease-Rich Digestive Enzymes for Improved Protein Breakdown Helps Maintain Healthy Gastrointestinal Flora Hectic lifestyles and overcooked food can make digestion less than optimal. Poor digestion can produce bloating and gas, cramping, diarrhea or constipation, and even food intolerances. Incomplete digestion of food proteins may also be linked to food allergies, and improper digestion of foodstuffs can cause foods to be fermented in the gut, and can lead to the proliferation of “bad” bacteria and yeast at the expense of “good” intestinal bacteria. More complete digestion removes a potential food source for these bad bacteria, allowing for the complete breakdown of food proteins which helps support regular bowel movements.Ultra Digestzyme is a full-spectrum enzyme strategically designed to support each phase of digestion. In the gastric phase, betaine HCl and pepsin prime the stomach, ensuring proper pH to initiate the first phase of digestion. This sets up for the second stage of digestion, the enteric phase, in which high-concentration protease, amylase, lipase, and trypsin are released and activated in the small intestine to ensure proper protein breakdown and fat absorption. This unique blend of high-powered enzymes works to enhance digestion and ensure maximum nutrient intake.  Suggested Use: 1-2 capsules before each meal or as recommended by your health care professional. Enzyme and Stomach Acid Depletion Since stomach acid and healthy digestive enzymes are essential for access to nutrients from foods, depletion of enzymes and hydrochloric acid may result in suboptimal nutritional status. Gastric Phase Digestion (Stomach) Betaine hydrochloride is an acidic form of betaine, used in the gastric phase to help bring the stomach to a more acidic pH to aid in digestion. Studies have shown the ability to secrete gastric acid decreases with age. Common symptoms of low gastric acidity include: bloating, belching, burning and flatulence immediately after meals, a sense of “fullness” after eating, indigestion, diarrhea or constipation, multiple food sensitivities, and nausea after taking supplements. Ultra Digestzyme also contains pepsin, a protease secreted in the stomach by chief cells for added digestive power in the gastric phase. Enteric Phase Digestion (Small Intestine) Pancreatin, bromelain, papain and ox bile extract support enteric phase digestion in the small intestine for further digestion of proteins and fats. Pancreatin extract is composed of three different enzymes: amylase, lipase and protease. All help to digest starch, protein and fat and enhance enzyme activity to support digestion. Eighty percent of pancreatic enzymes by weight are proteases. Lipase works with ox bile extract to emulsify and digest fats. Research has shown that papain, a protease derived from papaya, can help digest wheat gluten in the small intestine and render it harmless in those who are gluten sensitive. Finally, bromelain, an enzyme extracted from pineapple, aids in the digestion of protein and has been shown to help maintain normal levels of inflammation.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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