Clear Change

10-Day Metabolic Detoxification Program Highlights The Clear Change® 10-Day Program featuring UltraClear RENEW® is designed to enhance the body’s natural metabolic detoxification process while providing adequate fuel for both cleansing and other daily activities—providing energy and support for overall well-being. Many people benefit from completing a 10-day metabolic detoxification program two to three times a year.*Metabolic detoxification is a natural bodily process that consists of 3 major detoxification pathways: Phase I (functionalization), Phase II (conjugation), and Phase III (antiporter activity). In this process, fat soluble compounds must undergo transformation and become water-soluble before they can be excreted.The 10-day program is ideal for anyone wanting to benefit from an occasional “Spring Cleaning” or somebody who eats a reasonably healthy diet, exercises regularly, and manages stress adequately. It is also ideal for individuals who scored <50 on the Metabolic Detoxification Questionnaire.* Experience a Clear ChangeThe Clear Change Program, recommended by your healthcare provider, includes key nutritional support you need to start helping you feel your best.* Get started today! This box contains• UltraClear® RENEW Powder• AdvaClear® Capsules• Free shaker cup• Program guide with menu plan• Webinar invitation For more information, visit ClearChangeProgram.com   Other Ingredients: : Rice protein concentrate, pea protein isolate, bamboo fiber, olive oil, medium-chain triglycerides, natural flavors,^ silica, xanthan gum, Luo Han Guo fruit (monk fruit) extract, guar gum, rice maltodextrin, and hydrogenated palm oil.‡‡‡‡ Directions: Shake canister before scooping. Blend, shake or briskly stir about 2 level scoops (36 grams) of UltraClear RENEW into 8 fluid ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4-5 ounces of chilled water or juice twice daily during the first 3-4 days before starting a full daily dose. Warning: Not for use in patients with severe kidney disease or those with raised serum potassium levels or taking certain diuretics, cardiac, bladder or asthma medications. Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless instructed to do so by a healthcare practitioner. Caution: Recommended to be taken only as directed and under the supervision of a licensed healthcare practitioner. Do not use if pregnant or nursing. Keep out of reach of children. This product is non-GMO and gluten-free. Tamper Evident: Do not use if safety seal is missing or broken. Storage: Keep tightly closed in a cool, dry place. AdvaClear® Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica. Directions: Take two capsules once daily or as directed by your healthcare practitioner. This product is non-GMO and gluten-free. Warning: Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless directed to do so by a healthcare practitioner. Caution: If pregnant or nursing, taking other nutritional supplements, or taking medications, consult your healthcare practitioner before use. To be taken under supervision of a healthcare provider. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. *Percent Daily Values are based on a 2,000 calorie diet.**Daily Value not established † Vegetarian capsule†† Betatene® mixed carotenoids.††† As Metafolin® U.S. Patent Nos. 5,997,915; 6,254,904. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany‡ Brassinase is a trademark of VDF FutureCeuticals, Inc.‡‡ Contains no more than 4% caffeine‡‡‡ SOD B Extramel® is a registered trademark of Bionov.‡‡‡‡ RSPO certified (Roundtable on Sustainable Palm Oil)^ No MSG WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65warnings.ca.gov/food

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10-Day Metabolic Detoxification Program Highlights The Clear Change® 10-Day Program featuring UltraClear RENEW® is designed to enhance the body’s natural metabolic detoxification process while providing adequate fuel for both cleansing and other daily activities—providing energy and support for overall well-being. Many people benefit from completing a 10-day metabolic detoxification program two to three times a year.* Metabolic detoxification is a natural bodily process that consists of 3 major detoxification pathways: Phase I (functionalization), Phase II (conjugation), and Phase III (antiporter activity). In this process, fat soluble compounds must undergo transformation and become water-soluble before they can be excreted.The 10-day program is ideal for anyone wanting to benefit from an occasional “Spring Cleaning” or somebody who eats a reasonably healthy diet, exercises regularly, and manages stress adequately. It is also ideal for individuals who scored <50 on the Metabolic Detoxification Questionnaire.* Experience a Clear ChangeThe Clear Change Program, recommended by your healthcare provider, includes key nutritional support you need to start helping you feel your best.* Get started today! This box contains• UltraClear® RENEW Powder• AdvaClear® Capsules• Free shaker cup• Program guide with menu plan• Webinar invitation For more information, visit ClearChangeProgram.com Other Ingredients: Rice protein concentrate, pea protein isolate, bamboo fiber, gum acacia, olive oil, medium-chain triglycerides, natural flavors,^ silica, xanthan gum, Luo Han Guo fruit (monk fruit) extract, xanthan gum, guar gum, rice maltodextrin, and hydrogenated palm oil.‡‡‡‡ Directions: Shake canister before scooping. Blend, shake or briskly stir about 2 level scoops (36 grams) of UltraClear RENEW into 8 fluid ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4-5 ounces of chilled water or juice twice daily during the first 3-4 days before starting a full daily dose. Warning: Not for use in patients with severe kidney disease or those with raised serum potassium levels or taking certain diuretics, cardiac, bladder or asthma medications. Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless instructed to do so by a healthcare practitioner. Caution: Recommended to be taken only as directed and under the supervision of a licensed healthcare practitioner. Do not use if pregnant or nursing. Keep out of reach of children. This product is non-GMO and gluten-free. Tamper Evident: Do not use if safety seal is missing or broken. Storage: Keep tightly closed in a cool, dry place. AdvaClear® Other Ingredients:  Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica. Directions: Take two capsules once daily or as directed by your healthcare practitioner. This product is non-GMO and gluten-free. Warning: Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless directed to do so by a healthcare practitioner. Caution: If pregnant or nursing, taking other nutritional supplements, or taking medications, consult your healthcare practitioner before use. To be taken under supervision of a healthcare provider. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. *Percent Daily Values are based on a 2,000 calorie diet.**Daily Value not established † Vegetarian capsule†† Betatene® mixed carotenoids.††† As Metafolin® U.S. Patent Nos. 5,997,915; 6,254,904. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany‡ Brassinase is a trademark of VDF FutureCeuticals, Inc.‡‡ Contains no more than 4% caffeine‡‡‡ SOD B Extramel® is a registered trademark of Bionov.‡‡‡‡ RSPO certified (Roundtable on Sustainable Palm Oil)^ No MSG WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65warnings.ca.gov/food

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Highlights The Clear Change® 10-Day Program featuring UltraClear RENEW® is designed to enhance the body’s natural metabolic detoxification process while providing adequate fuel for both cleansing and other daily activities—providing energy and support for overall well-being. Many people benefit from completing a 10-day metabolic detoxification program two to three times a year.*Metabolic detoxification is a natural bodily process that consists of 3 major detoxification pathways: Phase I (functionalization), Phase II (conjugation), and Phase III (antiporter activity). In this process, fat soluble compounds must undergo transformation and become water-soluble before they can be excreted.The 10-day program is ideal for anyone wanting to benefit from an occasional “Spring Cleaning” or somebody who eats a reasonably healthy diet, exercises regularly, and manages stress adequately. It is also ideal for individuals who scored <50 on the Metabolic Detoxification Questionnaire.* Experience a Clear ChangeTheClear Change Program, recommended by your healthcare provider, includes key nutritional support you need to start helping you feel your best.* Get started today!  This box contains• UltraClear® RENEW Powder• AdvaClear® Capsules• Free shaker cup• Program guide with menu plan• Webinar invitation For more information, visit ClearChangeProgram.com Other Ingredients: Rice protein concentrate, pea protein isolate, bamboo fiber, olive oil, medium-chain triglycerides, gum acacia, hibiscus and black carrot juice (color), silica, citric acid, xanthan gum, Luo Han Guo fruit (monk fruit) extract, guar gum, natural flavors,^ rice maltodextrin, and hydrogenated palm oil.‡‡‡‡ Directions: Shake canister before scooping. Blend, shake or briskly stir about 2 level scoops (36 grams) of UltraClear RENEW into 8 fluid ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4-5 ounces of chilled water or juice twice daily during the first 3-4 days before starting a full daily dose. Warning: Not for use in patients with severe kidney disease or those with raised serum potassium levels or taking certain diuretics, cardiac, bladder or asthma medications. Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless instructed to do so by a healthcare practitioner. Caution: Recommended to be taken only as directed and under the supervision of a licensed healthcare practitioner. Do not use if pregnant or nursing. Keep out of reach of children. This product is non-GMO and gluten-free. Tamper Evident: Do not use if safety seal is missing or broken. Storage: Keep tightly closed in a cool, dry place. AdvaClear® Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica. Directions: Take two capsules once daily or as directed by your healthcare practitioner. This product is non-GMO and gluten-free. Warning: Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless directed to do so by a healthcare practitioner. Caution: If pregnant or nursing, taking other nutritional supplements, or taking medications, consult your healthcare practitioner before use. To be taken under supervision of a healthcare provider. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. *Percent Daily Values are based on a 2,000 calorie diet.**Daily Value not established † Vegetarian capsule†† Betatene® mixed carotenoids.††† As Metafolin® U.S. Patent Nos. 5,997,915; 6,254,904. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany‡ Brassinase is a trademark of VDF FutureCeuticals, Inc.‡‡ Contains no more than 4% caffeine‡‡‡ SOD B Extramel® is a registered trademark of Bionov.‡‡‡‡ RSPO certified (Roundtable on Sustainable Palm Oil)^ No MSG WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go towww.P65warnings.ca.gov/food 

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Metabolic Detoxification Program with UltraClear® RENEW Highlights The Clear Change 28-Day Program featuring UltraClear RENEW provides a more comprehensive approach to metabolic detoxification than the 10-day program. It’s an easy-to-follow eating plan with UltraClear RENEW nutritional powder mix and AdvaClear® dietary supplement capsules that will help patients get on track to feel better and more energized. Many people benefit from completing a 28-day metabolic detoxification program once or twice a year.*Metabolic detoxification is a natural bodily process that consists of 3 major detoxification pathways: Phase I (functionalization), Phase II (conjugation), and Phase III (antiporter activity). In this process, fat-soluble compounds must undergo transformation and become water-soluble before they can be excreted.The 28-day program is ideal for those who present with decreased vitality, individuals who eat a diet heavy in processed food and/or lacking in beneficial phytonutrients, or those who have a sedentary or high stress lifestyle. It is also ideal for individuals who scored >50 on the Metabolic Detoxification Questionnaire.*This convenient 28-day program includes:UltraClear RENEW (Berry, Chai, or Vanilla)—an advanced, specialized nutritional powder mix formulated for metabolic detoxification, including support for alkalinization, balanced liver detoxification capacity, and heavy metal metabolism* Features a low-allergy-potential rice protein base and is designed to help nutritionally support the detoxification of potentially harmful compounds by the liver and reduce exposure to food allergens* Supports Phase I and II detoxification, delivering nutrients to help enhance activities of several liver detoxification enzymes and antioxidants to help support the clearance of reactive intermediary compounds.* Provides advanced support for Phase III detoxification by nutritionally supporting alkalinity and excretion* AdvaClear®—supports balanced metabolic detoxification activity and provides antioxidant protection against reactive oxygen intermediates produced during the detoxification process. Delivers methylated vitamin B12 and folic acid along with nutrients designed to enhance the activities of several liver detoxification enzymes* Free shaker cup—convenient way to mix a nutritional powderProgram guide—easy-to-follow instructions, menu plans, and recipesFree webinar—on-demand presentation from Metagenics clinicians   UltraClear RENEW Vanilla Other Ingredients: Rice protein concentrate, pea protein isolate, isomalto-oligosaccharide, apple fiber, organic cane sugar, gum acacia, olive oil, medium-chain triglycerides, natural flavors,‡‡ silica, xanthan gum, Luo Han Guo fruit (monk fruit) extract, guar gum, rice maltodextrin, and hydrogenated palm oil.§ Directions: Blend, shake or briskly stir packet contents (40 grams) into 8 fluid ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. Warning: Not for use in patients with severe kidney disease or those with raised serum potassium levels or taking certain diuretics, cardiac, bladder or asthma medications. Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless instructed to do so by a healthcare practitioner. Caution: Recommended to be taken only as directed and under the supervision of a licensed healthcare practitioner. Do not use if pregnant or nursing. Keep out of reach of children. This product is non-GMO and gluten free. Storage: Keep in a cool, dry place. *Percent Daily Values are based on a 2,000 calorie diet. **Daily Value not established †As Metafolin®. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany ††Brassinase™ is a trademark of VDF FutureCeuticals, Inc. †††Contains no more than 4% caffeine ‡SOD B Extramel® is a registered trademark of Bionov. ‡‡No MSG §RSPO certified (Roundtable on Sustainable Palm Oil) AdvaClear Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica. Directions: Take two capsules once daily or as directed by your healthcare practitioner. This product is non-GMO and gluten-free. Warning: Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless directed to do so by a healthcare practitioner. Caution: If pregnant or nursing, taking other nutritional supplements, or taking medications, consult your healthcare practitioner before use. To be taken under supervision of a healthcare provider. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. *Daily Value not established. †Vegetarian capsule ††Betatene® mixed carotenoids. †††As Metafolin®. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany. U.S. Patent Nos. 5,997,915; 6,254,904. ‡Contains no more than 4% caffeine. WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65warnings.ca.gov/food

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Metabolic Detoxification Program with UltraClear® RENEW Highlights The Clear Change 28-Day Program featuring UltraClear RENEW provides a more comprehensive approach to metabolic detoxification than the 10-day program.It’s an easy-to-follow eating plan with UltraClear RENEW nutritional powder mix and AdvaClear® dietary supplement capsules that will help patients get on track to feel better and more energized. Many people benefit from completing a 28-day metabolic detoxification program once or twice a year.*Metabolic detoxification is a natural bodily process that consists of 3 major detoxification pathways: Phase I (functionalization), Phase II (conjugation), and Phase III (antiporter activity). In this process, fat-soluble compounds must undergo transformation and become water-soluble before they can be excreted.The 28-day program is ideal for those who present with decreased vitality, individuals who eat a diet heavy in processed food and/or lacking in beneficial phytonutrients, or those who have a sedentary or high stress lifestyle. It is also ideal for individuals who scored >50 on the Metabolic Detoxification Questionnaire.*This convenient 28-day program includes:UltraClear RENEW (Berry, Chai, or Vanilla)—an advanced, specialized nutritional powder mix formulated for metabolic detoxification, including support for alkalinization, balanced liver detoxification capacity, and heavy metal metabolism* Features a low-allergy-potential rice protein base and is designed to help nutritionally support the detoxification of potentially harmful compounds by the liver and reduce exposure to food allergens* Supports Phase I and II detoxification, delivering nutrients to help enhance activities of several liver detoxification enzymes and antioxidants to help support the clearance of reactive intermediary compounds.* Provides advanced support for Phase III detoxification by nutritionally supporting alkalinity and excretion* AdvaClear®—supports balanced metabolic detoxification activity and provides antioxidant protection against reactive oxygen intermediates produced during the detoxification process. Delivers methylated vitamin B12 and folic acid along with nutrients designed to enhance the activities of several liver detoxification enzymes* Free shaker cup—convenient way to mix a nutritional powderProgram guide—easy-to-follow instructions, menu plans, and recipesFree webinar—on-demand presentation from Metagenics clinicians   Other Ingredients: Rice protein concentrate, pea protein isolate, bamboo fiber, olive oil, medium-chain triglycerides, natural flavors,‡‡ silica, xanthan gum, Luo Han Guo fruit (monk fruit) extract, guar gum, rice maltodextrin, and hydrogenated palm oil.§ Directions: Shake canister before scooping. Blend, shake or briskly stir about 2 level scoops (36 grams) of UltraClear RENEW into 8 fluid ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4-5 ounces of chilled water or juice twice daily during the first 3-4 days before starting a full daily dose. Warning: Not for use in patients with severe kidney disease or those with raised serum potassium levels or taking certain diuretics, cardiac, bladder or asthma medications. Excess vitamin A may contribute to a risk of birth defects. Pregnant women and women who may become pregnant should not exceed 3,000 mcg of preformed vitamin A (retinyl palmitate) per day unless instructed to do so by a healthcare practitioner. Caution: Recommended to be taken only as directed and under the supervision of a licensed healthcare practitioner. Do not use if pregnant or nursing. Keep out of reach of children. This product is non-GMO and gluten-free. Tamper Evident: Do not use if safety seal is missing or broken. Storage: Keep tightly closed in a cool, dry place. *Percent Daily Values are based on a 2,000 calorie diet.**Daily Value not established † As Metafolin®. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany†† Brassinase™ is a trademark of VDF FutureCeuticals, Inc.††† Contains no more than 4% caffeine‡ SOD B Extramel® is a registered trademark of Bionov.‡‡ No MSG§ RSPO certified (Roundtable on Sustainable Palm Oil) *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. AdvaClear Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica. Directions: Take two capsules once daily or as directed by your healthcare practitioner. This product is non-GMO and gluten-free. Warning: Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless directed to do so by a healthcare practitioner. Caution: If pregnant or nursing, taking other nutritional supplements, or taking medications, consult your healthcare practitioner before use. To be taken under supervision of a healthcare provider. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. *Daily Value not established. †Vegetarian capsule ††Betatene® mixed carotenoids. †††As Metafolin®. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany. U.S. Patent Nos. 5,997,915; 6,254,904. ‡Contains no more than 4% caffeine. WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65warnings.ca.gov/food

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Highlights Clear Change® Daily Essentials is a premium packet containing 3 nutritional supplements designed to complement your daily foundation nutrition program and support daily detoxification following the Clear Change Metabolic Detoxification Program. This 1-month program features AdvaClear®, GlutaClear®, and Renagen™ DTX for targeted, daily support.* Each once-daily packet provides:Bifunctional detoxification support: AdvaClear® promotes vitality and health by supporting balanced activity of the Phase 1 and Phase 2 detoxification pathways. This formula provides methylated vitamin B12 and folic acid along with nutrients designed to enhance the activities of several liver detoxification enzymes.* Antioxidant protection & detoxification support: GlutaClear® features a blend of key ingredients, including antioxidant vitamins, designed to help boost the body’s production of glutathione. Glutathione plays an important role in protecting the body against oxidative stress and protecting cellular health.* Kidney health: Renagen™ DTX is a specific blend of nutrients and traditional herbs designed to support healthy kidney function.* The Metagenics DifferenceMetagenics is one of the few professional nutraceutical companies that formulates and evaluates nutritional products in clinical practice. Each Clear Change Daily Essentials formula is science based and delivers optimized, targeted health support.*   Each packet contains: 2 AdvaClear capsules (light brown), 1 GlutaClear tablet (white), and 1 Renagen DTX capsule (green)AdvaClear:Other Ingredients: Capsule‡ (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica.GlutaClear:Other Ingredients: Microcrystalline cellulose, cellulose, stearic acid (vegetable), silica, and coating (hypromellose, medium-chain triglycerides, and hydroxypropylcellulose). Renagen DTX:Other Ingredients: Capsule‡ [hydroxypropylmethylcellulose, sodium copper chlorophyllin (color), and gellan gum], microcrystalline cellulose, and magnesium stearate (vegetable).   Directions: Take one packet daily for one to two months or as directed by your healthcare practitioner. Products included are non-GMO and gluten-free. Warning: Do not use if taking blood thinning medications, antihypertensive medications, hypoglycemic medications and insulin, digoxin or nitroglycerin, or before surgery. Caution: If pregnant or nursing, or if taking other nutritional supplements or medications, consult your healthcare practitioner before use. Tamper Evident: Do not use if package is torn or open. Storage: Keep in a cool, dry place. *Percent Daily Values are based on a 2,000 calorie diet.**Daily Value not established. † As Betatene® mixed carotenoids.†† As Metafolin®. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany. U.S. Patent Nos. 5,997,915; 6,254,904.††† Contains no more than 4% caffeine.‡ Vegetarian capsule. Serving Size 1 Packet Daily Value Servings Per Container 30   Total Carbohydrate <1 g <1%*  Dietary Fiber <1 g 3%* Vitamin A (from mixed carotenoids† and retinyl palmitate) 750 mcg 83% Vitamin C (as ascorbic acid) 383 mg 426% Vitamin D (as cholecalciferol) 0.8 mcg (33 IU) 4% Vitamin E (as d-alpha tocopheryl succinate) 44.8 mg 299% Thiamin (as thiamin mononitrate) 10 mg 833% Riboflavin 5 mg 385% Niacin (as niacinamide and niacin) 398 mg 2,488% Vitamin B6 (as pyridoxine HCl) 27 mg 1,588% Folate (as calcium L-5-methyltetrahydrofolate††) 1,135 mcg DFE 284% Vitamin B12 (as methylcobalamin) 158 mcg 6,583% Biotin 66 mcg 220% Pantothenic Acid (as d-calcium pantothenate) 33 mg 660% Zinc (as zinc citrate) 6.5 mg 59% Selenium (as selenomethionine) 87 mg 158% Copper (as copper citrate) 0.65 mg 72% Manganese (as manganese citrate) 1.65 mg 72% Molybdenum (as molybdenum aspartate) 66 mcg 147% N-Acetyl-L-Cysteine 642 mg ** Chinese Salvia Root (Salvia miltiorrhiza) 200 mg ** Cordyceps Mycelium Extract (Paecilomyces hepiali Chen) [standardized to 4% (8 mg) cordycepic acid and 0.25% (0.5 mg) adenosine] 200 mg ** Artichoke (Cynara scolymus) Leaf Extract (containing cynarin and chlorogenic acid) 167 mg ** Watercress (Nasturtium officinale) Aerial Parts 4:1 Extract 133 mg ** Taurine 117 mg ** Sodium Sulfate 100 mg ** Pomegranate (Punica granatum L.) Whole Fruit Extract [standardized to 45.8 mg gallic acid equivalent (GAE)] 87.5 mg ** Decaffeinated††† Green Tea (Camellia sinensis) Leaf Extract [standardized to 60% (33.6 mg) catechins and 40% (22.4 mg) epigallocatechin gallate (EGCG)] 56 mg ** Silymarin (from milk thistle seed extract, Silybum marianum) 50 mg ** Broccoli (Brassica oleracea L. var. italica) Seed Extract (providing 2.5 mg glucoraphanin) 19.25 mg **

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Highlights The Clear Change 28-Day Program featuring UltraClear RENEW provides a more comprehensive approach to metabolic detoxification than the 10-day program.It’s an easy-to-follow eating plan with UltraClear RENEW nutritional powder mix and AdvaClear® dietary supplement capsules that will help patients get on track to feel better and more energized. Many people benefit from completing a 28-day metabolic detoxification program once or twice a year.*Metabolic detoxification is a natural bodily process that consists of 3 major detoxification pathways: Phase I (functionalization), Phase II (conjugation), and Phase III (antiporter activity). In this process, fat-soluble compounds must undergo transformation and become water-soluble before they can be excreted.The 28-day program is ideal for those who present with decreased vitality, individuals who eat a diet heavy in processed food and/or lacking in beneficial phytonutrients, or those who have a sedentary or high stress lifestyle. It is also ideal for individuals who scored >50 on the Metabolic Detoxification Questionnaire.*This convenient 28-day program includes:UltraClear RENEW (Berry, Chai, or Vanilla)—an advanced, specialized nutritional powder mix formulated for metabolic detoxification, including support for alkalinization, balanced liver detoxification capacity, and heavy metal metabolism* Features a low-allergy-potential rice protein base and is designed to help nutritionally support the detoxification of potentially harmful compounds by the liver and reduce exposure to food allergens* Supports Phase I and II detoxification, delivering nutrients to help enhance activities of several liver detoxification enzymes and antioxidants to help support the clearance of reactive intermediary compounds.* Provides advanced support for Phase III detoxification by nutritionally supporting alkalinity and excretion* AdvaClear®—supports balanced metabolic detoxification activity and provides antioxidant protection against reactive oxygen intermediates produced during the detoxification process. Delivers methylated vitamin B12 and folic acid along with nutrients designed to enhance the activities of several liver detoxification enzymes* Free shaker cup—convenient way to mix a nutritional powderProgram guide—easy-to-follow instructions, menu plans, and recipesFree webinar—on-demand presentation from Metagenics clinicians   UltraClear RENEW Berry Other Ingredients:  Rice protein concentrate, pea protein isolate, bamboo fiber, olive oil, medium-chain triglycerides, gum acacia, hibiscus and black carrot juice (color), silica, citric acid, xanthan gum, Luo Han Guo fruit (monk fruit) extract, guar gum, natural flavors,‡‡ rice maltodextrin, and hydrogenated palm oil. § Directions: Shake canister before scooping. Blend, shake or briskly stir about 2 level scoops (36 grams) of UltraClear RENEW into 8 fluid ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4-5 ounces of chilled water or juice twice daily during the first 3-4 days before starting a full daily dose. Warning: Not for use in patients with severe kidney disease or those with raised serum potassium levels or taking certain diuretics, cardiac, bladder or asthma medications. Excess vitamin A may contribute to a risk of birth defects. Pregnant women and women who may become pregnant should not exceed 3,000 mcg of preformed vitamin A (retinyl palmitate) per day unless instructed to do so by a healthcare practitioner. Caution: Recommended to be taken only as directed and under the supervision of a licensed healthcare practitioner. Do not use if pregnant or nursing. Keep out of reach of children. This product is non-GMO and gluten-free. Tamper Evident: Do not use if safety seal is missing or broken. Storage: Keep tightly closed in a cool, dry place. *Percent Daily Values are based on a 2,000 calorie diet.**Daily Value not established † As Metafolin®. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany†† Brassinase™ is a trademark of VDF FutureCeuticals, Inc.††† Contains no more than 4% caffeine‡ SOD B Extramel® is a registered trademark of Bionov.‡‡ No MSG§ RSPO certified (Roundtable on Sustainable Palm Oil) *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.   AdvaClear Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica. Directions: Take two capsules once daily or as directed by your healthcare practitioner. This product is non-GMO and gluten-free. Warning: Excess vitamin A intake may be toxic, may increase the risk of birth defects, and may contribute to osteoporosis. Pregnant women and women who may become pregnant should not exceed 10,000 IU of preformed vitamin A (retinyl palmitate) per day unless directed to do so by a healthcare practitioner. Caution: If pregnant or nursing, taking other nutritional supplements, or taking medications, consult your healthcare practitioner before use. To be taken under supervision of a healthcare provider. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. *Daily Value not established. †Vegetarian capsule ††Betatene® mixed carotenoids. †††As Metafolin®. Metafolin® is a registered trademark of Merck KGaA, Darmstadt Germany. U.S. Patent Nos. 5,997,915; 6,254,904. ‡Contains no more than 4% caffeine. WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65warnings.ca.gov/food

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