Cardiovascular/Heart Health

 Active Mag includes three forms of highly absorbed magnesium for a variety of protocols. Provides Three Forms of Highly Absorbed Magnesium for a Variety of Protocols High-Concentration Magnesium for Cardiovascular Support Helps Maintain Healthy Blood Pressure and Glucose Levels Promotes Energy Production and Muscle Relaxation Magnesium is an abundant mineral in the body and is found naturally in many foods, like green leafy vegetables. It is also found in over-the-counter medications, such as laxatives. The average American intake of magnesium, according to the National Health and Nutrition Examination Survey (NHANES Study) is critically low: Many Americans fail to consume the estimated average requirement (EAR) established by the Institute of Medicine. In addition, more than 57% of the population does not meet the United States Department of Agriculture requirements for magnesium in the diet. Intracellular magnesium levels are decreased by excessive intake of alcohol, salt, coffee, phosphoric acid found in sodas, diets high in calcium and high stress levels. Because of widespread nature of magnesium deficiencies, adequate daily intake of magnesium is critical for proper hydration, stress response, muscle relaxation, promoting healthy blood pressure levels, optimal bone mineral density, and blood sugar regulation. Active Mag provides three unique forms of highly-absorbed magnesium to ensure maximum absorption of this important macromineral. Most magnesium supplements use only a single source of magnesium, which can easily overwhelm a single pathway of absorption and limit uptake. Reacted Magnesium takes advantage of three unique pathways of absorption by providing magnesium as di-magnesium malate, magnesium citrate and magnesium glycinate for enhanced absorption, improved utilization and gastrointestinal (GI) comfort. Some individuals, who take other forms of magnesium supplements, often experience GI side effects, including gas, bloating, diarrhea, constipation or a combination of these symptoms. The forms of magnesium used in Reacted Magnesium preserve GI comfort while maximizing absorption and restoring magnesium levels in the body. Suggested Use: 2 or more capsules per day or as recommended by your health care professional. Bioavailability - The Mineral Chelate Difference The importance of bioavailability is obvious. If consuming a magnesium supplement has little effect on improving the body’s magnesium balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rock-salt minerals like calcium carbonate and magnesium oxide. These mineral forms slow and limit absorption, relying on adequate stomach acid to release magnesium ions which then enter the body via passive diffusion. And, because they tend to remain in the intestines longer, these forms of mineral supplements can cause intestinal distress such as constipation (calcium carbonate) or diarrhea (magnesium oxide). In addition, other comparison studies have shown significantly superior absorption of magnesium chelates compared to other mineral forms: At a dose of 400 mg, magnesium chelate significantly reduced or eliminated menstrual abdominal discomfort. Multiple double blind studies found urinary excretion of magnesium chloride higher than magnesium glycinate, proving superior absorption. Magnesium glycinate is shown to have a reduced laxative effect when compared to other forms of magnesium. Mineral chelates are gentle, gut “friendly” minerals that do not cause diarrhea that often accompanies magnesium oxide and other rock-salt forms. Albion®’s mineral chelates have extensive clinical research proving their superior bioavailability, biologic activity, stability, and improved tolerance.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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Methyl B includes a concentrated and bioavailable source of two key B vitamins: B12 and folate. This comprehensive blend helps support numerous systems in the body. Includes High-Concentration, Fast-Absorbing Bioactive Methylcobalamin and Methylfolate (100% as 5-MTHF) Boosts Energy Levels and Supports Red Blood Cell Production Promotes Cardiovascular Health and Homocysteine Balance Rejuvenates Nerve Cell Function and Boosts Cognitive Health Supports a Positive Mood and Healthy Sleep Cycle Regulation Vitamin B works along with folate in many body processes. These include increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function, up-regulating methylation, increasing DNA synthesis and repair, and supporting the formation of the protective myelin sheath, the insulating exterior that speeds up nerve cell transmission.Most B supplements contain cyanocobalamin. In order for B to be utilized in the body, the liver must first remove the cyanide molecule and attach a methyl group to form methylcobalamin, the biologically active, tissue-ready form. Research has shown that methylcobalamin is more efficiently used and retained in the body than the cyanocobalamin form.This formulation of Methyl B includes a concentrated and bioavailable source of two key B vitamins: B12 and folate.Suggested Use:1 tablet per day or as recommended by your health care professional.   Energy Support Vitamin B plays a large role as a cofactor in enzymes involved in the metabolism of proteins, fats and carbohydrates, and is required to produce succinyl CoA, an intermediary in the Kreb's cycle that generates cellular energy in the form of adenosine triphosphate (ATP). Due to its role in the production of ATP, vitamin B deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels.Peripheral Circulation and Nerve Cell HealthIn a double-blind study, oral administration of methylcobalamin (500 mcg three times daily for four months) showed a significant improvement in neuromuscular health. The subjects in the control group reported improvement in muscle aches, fatigue, sensitivity to pain, circulation, muscle cramps and reflexes.Cardiovascular Health and Homocysteine BalanceHomocysteine is a molecule which is synthesized in the body from the amino acid methionine. Maintaining healthy homocysteine balance is crucial for supporting arterial and cardiovascular health. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance. 5-MTHF acts as a methyl donor, providing a methyl group to vitamin B12. The methylated form of B (methylcobalamin) then transfers the methyl group to homocysteine, resulting in consistent recycling of homocysteine to methionine.Mental and Cognitive HealthB has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of s-adenosylmethionine (SAM-e), a nutrient that has powerful mood and sleep-cycle regulating properties. Due to B12’s ability to increase the production of neurotransmitters and nerve cell transmission, B12 has been shown to improve cognitive function. 5-MTHF plays a significant role in mood regulation as it is required as a methyl group donor for the production of neurotransmitters such as serotonin. Sleep Cycle RegulationMethylcobalamin and 5-MTHF are both required nutrients for the biosynthesis of melatonin, the hormone that helps induce sleep. Within the central nervous system, the neurotransmitter serotonin is converted into melatonin in a pathway that requires the donation of a methyl group.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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In addition to supporting bone health, vitamin D plays an important role maintaining cardiovascular health and immune function, and promoting an overall sense of well-being. Product Overview Clinical Applications Maintains Bone and Dental Health Increases Calcium Absorption and Balance Boosts Immune Activity Supports Cardiometabolic Health, Blood Sugar Balance Already Within Normal Levels, and Weight Loss Helps Increase Musculoskeletal Strength and Comfort D3 50,000 is a steroid hormone that is part of a group of fat-soluble pro-hormones best known for the role they play in supporting bone health and aiding in the absorption of calcium and phosphate from the gastrointestinal tract. A growing body of research highlights vitamin D's important role in supporting other body systems, including cardiovascular and blood sugar balance, musculoskeletal strength, and neurological and immune function, enabled by vitamin D's ability to target over 200 different genes throughout the body.D3 50,000 IU is ideal for those who have difficulty achieving and maintaining peak vitamin D levels. For those who require an immediate boost in their vitamin D status, the vitamin D3 50,000 IU formulation is a convenient, effective way to get the substantial support they need. Suggested Use:1 capsule per week. This product is a high dose vitamin D capsule that is not typically intended for long-term daily use. Please consult your health care professional if you are unsure of the appropriate dose. Benefits Vitamin D DepletionWhile it has long been assumed that the majority of the population achieves adequate levels of vitamin D through exposure to the sun, the biosynthesis of the nutrient is affected by time of day, seasons, location, smog/pollution, clothing and sunscreen. Depleted levels of vitamin D may interfere with the normal development of teeth and bones, normal cell growth, and contribute to poor regulation of immune and nervous systems. Bone and Dental HealthNumerous studies have highlighted the importance of vitamin D to maintaining healthy bone density.Cardiometabolic Health and Blood Sugar BalanceIn light of the role that vitamin D plays in a variety of tissues and body systems, it comes as no surprise that much research from recent years has underscored its contribution to cardiometabolic wellness. Vitamin D has also been shown to support healthy blood sugar metabolism. Immune Health and ModulationOne of the more profound functions of vitamin D is its ability to modulate immunity. An important recent study suggested that improving vitamin D status significantly affects the expression of genetic pathways linked to immune activity. Vitamin D has been shown to boost the immune response by up-regulating specific genes.Musculoskeletal ComfortNumerous studies also point to the key role of vitamin D in supporting musculoskeletal strength and comfort.Safety and Efficacy of High Dose Vitamin DVitamin D research is continually evolving and now includes safety and efficacy studies on high doses of up to 50,000 IU. Vitamin D 50000 Supplement Facts Serving Size 1 Capsule Servings Per Container 15  Amount Per Serving % Daily Value Vitamin D (D3 as Cholecalciferol) 1,250 mcg (50,000 IU) 6,250%

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Highlights Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and maintain normal ranged blood pressure levels. Supports Healthy Blood Flow and Circulation Supports Healthy Fibrin Levels Helps Maintain Healthy Blood Pressure Supports Overall Cardiovascular Health Maintaining healthy blood circulation and balanced coagulation is a key part of supporting cardiovascular health. Fibrinolytic enzymes, such as plasmin, produced in the endothelial cells are responsible for ensuring proper blood flow. However, production of these enzymes decreases with age, which can result in increased fibrin levels. Nattokinase also inhibits a key enzyme resulting in arterial dilation to help maintain healthy blood pressure levels, and can generate tissue plasminogen activators helping to promote blood flow. Because it is a highly purified extract derived from soybeans, supplementing nattokinase differs from consuming soybeans in that nattokinase escapes the typical breakdown by digestive enzymes, and is absorbed and taken into the body directly from the small intestine to exert its effects in the plasma. Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and blood pressure levels. Derived from a highly purified extract of the traditional Japanese food natto, nattokinase is a natural, highly active enzyme that helps promote normal levels of fibrin. Fibrin is a filamentous protein formed in blood, which can accumulate along blood vessel walls and affect blood flow. Research has shown nattokinase closely resembles plasmin, the only endogenous enzyme that directly dissolves fibrin. It is thought to increase the body’s production of plasmin. Nattokinase has been shown to support activation of many of the body’s 3,000 endogenous enzymes. In addition, while many of the agents involved in promoting healthy blood flow and coagulation either have limitations, and or serious side effects, this formulation of Nattokinase has a potent support activity that lasts for an 8-12 hour period and is safe for long-term use. Each capsule of Nattokinase contains 100 mg of nattokinase. Suggested Use: 1 soft gel capsule two times per day or as recommended by your health care professional.

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Highlights Vitamins K and D act in synergy in the process of supporting and maintaining bone, cardiovascular and immune health.  Supports Healthy Calcium Balance Promotes Optimal Bone Health Supports Cardiovascular Health and Arterial Elasticity Boosts Immune Function Emerging research highlights the importance of optimal intake of vitamin K and its critical role in maintaining bone and cardiovascular health. Composed of a group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is required for the proper utilization of calcium and helps to bind newly absorbed calcium to the bone matrix. Vitamin K helps maintain bone mineral density by decreasing the activity of osteoclasts, cells that break down bone. It also provides critical cardiovascular protection by activating matrix Gla protein (MGP), a potent inhibitor of circulatory calcification. Along with vitamin D, another key nutrient required for overall wellness, these two nutrients act in synergy to support and maintain bone and cardiovascular health. Current research has found high concentration supplementation, at 180 mcg/day, results in improved clinical results compared to lower-dose supplementation. Suggested Use: 1 capsule per day or as recommended by your health care professional. Vitamin K Depletion Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K, through its carboxylation of osteocalcin, a protein secreted by osteoblasts. Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in two main forms: K1 (phylloquinone), derived from foods such as green leafy vegetables and K2 (menaquinone), which is a group of related compounds differentiated by their side chains. Numerous studies have shown that vitamin K2 as MK-7 is the more bioavailable form of the nutrient 7 and more powerfully influences bone building than K1.  Bone Health Supplementation of K2 has repeatedly been shown to help maintain bone density and strength among women.  Cardiovascular Health and Blood Sugar Balance Vitamin K also plays a key role in supporting the cardiovascular system and healthy blood sugar balance. In a large population study, those who consumed high amounts of K2 had significantly improved cardiovascular markers compared to those given vitamin K1. Triage Theory The Triage Theory states that in the face of nutrient inadequacies, nature ensures the short-term survival of a cell is protected at the expense of long-term consequences. Vitamin K is an excellent example of this theory. Hypothetically, a short-term deficiency in vitamin K would lead to a reduction in blood clotting. This direct threat to survival does not happen because the body uses its metabolic reserve of vitamin K to ensure immediate needs are met. If prolonged, this dip into nutrient reserves leads to a long-term deficiency in vitamin K. Though not directly threatening immediate survival, long-term deficiencies are linked to bone fragility, arterial calcification and genomic instability.   

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Highlights Helps Maintain Healthy Cholesterol Levels Already Within the Normal Range Multidimensional Support for Cardiovascular Health Preserves Arterial Health and Elasticity Supports Healthy CoQ-10 Levels Optimizing cardiovascular health is a leading concern for many adults, and maintaining balanced cholesterol levels are an important part of that process. Though cholesterol can be consumed through food, circulating cholesterol levels are primarily produced and controlled by the liver using the rate control enzyme, HMG-CoA reductase (HMGCR). Because of its pronounced role in cholesterol synthesis, inhibiting HMGCR has become a primary target of many traditional therapies. Numerous clinical trials have shown the specific BPF found in Bergamot BPF works at the level of the liver to help maintain and support healthy cholesterol levels and preserve coronary arteries by maintaining normal inflammatory balance. Suggested Use: 2 capsules per day or as recommended by your health care professional. What are Bergamot Polyphenolic Fractions? Bergamot (Citrus bergamia) is a citrus plant that grows almost exclusively in the narrow coastal Calabria region in southern Italy. The local population quickly discovered bergamot juice could be used to help support healthy cholesterol levels and optimize cardiovascular wellness. Bergamot’s health benefits derive from its unique profile of phenolic compounds such as, neoeriocitrin, neohesperidin, naringin, rutin, neodesmin, rhoifolin and poncirin. Naringin has been shown to be beneficial in maintaining normal inflammatory balance, while neoeriocitrin and rutin have been found to exhibit a strong capacity to quench free radicals and maintain healthy LDL cholesterol levels. Also, bergamot is rich in brutieridine and melitidine, which have a unique ability to dampen HMG-CoA reductase.

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Methyl B12 includes a concentrated and bioavailable source of two key B vitamins: B12 and folate. This comprehensive blend helps support numerous systems in the body. Includes High-Concentration, Fast-Absorbing Bioactive Methylcobalamin and Methylfolate (100% as 5-MTHF) Boosts Energy Levels and Supports Red Blood Cell Production Promotes Cardiovascular Health and Homocysteine Balance Rejuvenates Nerve Cell Function and Boosts Cognitive Health Supports a Positive Mood and Healthy Sleep Cycle Regulation Vitamin B12 works along with folate in many body processes. These include increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function, up-regulating methylation, increasing DNA synthesis and repair, and supporting the formation of the protective myelin sheath, the insulating exterior that speeds up nerve cell transmission.Most B12 supplements contain cyanocobalamin. In order for B12 to be utilized in the body, the liver must first remove the cyanide molecule and attach a methyl group to form methylcobalamin, the biologically active, tissue-ready form. Research has shown that methylcobalamin is more efficiently used and retained in the body than the cyanocobalamin form.This formulation of Methyl B12 includes a concentrated and bioavailable source of two key B vitamins: B12 and folate. Suggested Use:1 tablet per day or as recommended by your health care professional.   Energy Support Vitamin B12 plays a large role as a cofactor in enzymes involved in the metabolism of proteins, fats and carbohydrates, and is required to produce succinyl CoA, an intermediary in the Kreb's cycle that generates cellular energy in the form of adenosine triphosphate (ATP). Due to its role in the production of ATP, vitamin B12 deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels.Peripheral Circulation and Nerve Cell HealthIn a double-blind study, oral administration of methylcobalamin (500 mcg three times daily for four months) showed a significant improvement in neuromuscular health. The subjects in the control group reported improvement in muscle aches, fatigue, sensitivity to pain, circulation, muscle cramps and reflexes.Cardiovascular Health and Homocysteine BalanceHomocysteine is a molecule which is synthesized in the body from the amino acid methionine. Maintaining healthy homocysteine balance is crucial for supporting arterial and cardiovascular health. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance. 5-MTHF acts as a methyl donor, providing a methyl group to vitamin B12. The methylated form of B12 (methylcobalamin) then transfers the methyl group to homocysteine, resulting in consistent recycling of homocysteine to methionine.Mental and Cognitive HealthB12 has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of s-adenosylmethionine (SAM-e), a nutrient that has powerful mood and sleep-cycle regulating properties. Due to B12’s ability to increase the production of neurotransmitters and nerve cell transmission, B12 has been shown to improve cognitive function. 5-MTHF plays a significant role in mood regulation as it is required as a methyl group donor for the production of neurotransmitters such as serotonin. Sleep Cycle RegulationMethylcobalamin and 5-MTHF are both required nutrients for the biosynthesis of melatonin, the hormone that helps induce sleep. Within the central nervous system, the neurotransmitter serotonin is converted into melatonin in a pathway that requires the donation of a methyl group.   These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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